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Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

《化学科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 362-368 doi: 10.1007/s11705-014-1439-5

摘要： A methodology to develop multi-component drugs based on traditional Chinese medicines has been developed using central composite design. Several active components from the traditional Chinese medicine turmeric were chosen for use in a multi-component antitumor drug. Response surface methodology based on a central composite design was applied to determine the quantitative composition-activity relationships in order to optimize the amount of each component in the drug. An MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to measure the pharmacological activity as the response value. The experimental antitumor activity of the optimum combination was 92.85% in the MTT assay and superior to the activities of each single component. These results demonstrate that response surface methodology based on a central composite design is suitable for the design of multi-component drugs.

关键词： multi-component drug development     central composite design     turmeric     curcuminoids    

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Molecular level simulations on multi-component systems —a morphology prediction method

C. SCHMIDT, J. ULRICH

《化学科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 49-54 doi: 10.1007/s11705-013-1307-8

摘要： The crystal morphology grown from a solution composed of an organic solvent, solute and additive can be predicted reliably by a computational method. Modeling the supersaturated solution as liquid phase is achieved by employing commercial software. The molecular composition of this solution is a required input parameter. The face specific diffusion coefficient of the solid (crystal surface) and liquid (solution) system is determined using the molecular dynamics procedure. The obtained diffusion coefficient is related to the specific face growth rate via the attachment energy of the pure morphology. The significant improvements are achieved in the morphology prediction because the investigation on the face growth rates in a complex growth environment (as multi-component solutions with additives) can be carried out based on the diffusion coefficients.

关键词： crystallization     morphology     molecular dynamics     solution    

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Multi-Component Resource Recycling from Waste Light-Emitting Diode Under Hydrothermal Condition: Plastic

Yongliang Zhang,Lu Zhan,Zhenming Xu,

《工程（英文）》 doi: 10.1016/j.eng.2023.04.008

摘要： Light emitting diodes (LEDs) have accounted for most of the lighting market as the technology matures and costs continue to reduce. As a new type of e-waste, LED is a double-edged sword, as it contains not only precious and rare metals but also organic packaging materials. In previous studies, LED recycling focused on recovering precious and strategic metals while ignoring harmful substances such as organic packaging materials. Unlike crushing and other traditional methods, hydrothermal treatment can provide an environment-friendly process for decomposing packaging materials. This work developed a closed reaction vessel, where the degradation rate of plastic polyphthalamide (PPA) was close to 100%, with nano-TiO2 encapsulated in plastic PPA being efficiently recovered, while metals contained in LED were also recycled efficiently. Besides, the role of water in plastic PPA degradation that has been overlooked in current studies was explored and speculated in detail in this work. Environmental impact assessment revealed that the proposed recycling route for waste LED could significantly reduce the overall environmental impact compared to the currently published processes. Especially the developed method could reduce more than half the impact of global warming. Furthermore, this research provides a theoretical basis and a promising method for recycling other plastic-packaged e-waste devices, such as integrated circuits.

关键词： Waste LED     Hydrothermal treatment     Recycling     Plastic PPA degradation     Packaging materials    

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The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

《医学前沿（英文）》 2007年 第1卷 第4期   页码 423-428 doi: 10.1007/s11684-007-0083-6

摘要： This paper reported the epidemiology of the colistin-only-sensitive (COS-AB) in a tertiary teaching hospital in China. We analyzed the clinical data of 136 COS-AB isolates from June 2004 to May 2005 and collected 66 . isolates in which 33 strains were COS-AB, and the rest were non-COS-AB. Random amplified polymorphic DNA (RAPD) analysis (primer ERIC2 and 272) showed that all COS-AB were identical, while pulsed-field gel electrophotesis (PFGE) analysis showed two separate genotypes of these COS-AB which were distinctly different from that of non-COS-AB. The COS-AB from burn wards showed the identical PFGE pattern which was distinguished from the genotype of COS-AB in other departments, mainly surgical systems. The cross-infection was severe and strict methods of disinfection and sterilization should be implemented. Meanwhile, the epidemiology of COS-AB in environment and patients should be closely monitored. The PFGE analysis is a reliable method of . typing.

关键词： identical     different     teaching hospital     genotype     colistin-only-sensitive    

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Cholera: an overview with reference to the Yemen epidemic

Ali A. Rabaan

《医学前沿（英文）》 2019年 第13卷 第2期   页码 213-228 doi: 10.1007/s11684-018-0631-2

摘要： Cholera is a secretory diarrhoeal disease caused by infection with , primarily the O1 El Tor biotype. There are approximately 2.9 million cases in 69 endemic countries annually, resulting in 95 000 deaths. Cholera is associated with poor infrastructure and lack of access to sanitation and clean drinking water. The current cholera epidemic in Yemen, linked to spread of O1 (Ogawa serotype), is associated with the ongoing war. This has devastated infrastructure and health services. The World Health Organization had estimated that 172 286 suspected cases arose between 27th April and 19th June 2017, including 1170 deaths. While there are three oral cholera vaccines prequalified by the World Health Organization, there are issues surrounding vaccination campaigns in conflict situations, exacerbated by external factors such as a global vaccine shortage. Major movements of people complicates surveillance and administration of double doses of vaccines. Cholera therapy mainly depends on rehydration, with use of antibiotics in more severe infections. Concerns have arisen about the rise of antibiotic resistance in cholera, due to mobile genetic elements. In this review, we give an overview of cholera epidemiology, virulence, antibiotic resistance, therapy and vaccines, in the light of the ongoing epidemic in Yemen.

关键词： cholera     epidemic     multi-drug resistant     catechin     luteolin     ToxT     CTX&Fcy    

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Multi-objective optimization of cutting parameters in high-speed milling based on grey relational analysiscoupled with principal component analysis

Tao FU, Jibin ZHAO, Weijun LIU

《机械工程前沿（英文）》 2012年 第7卷 第4期   页码 445-452 doi: 10.1007/s11465-012-0338-z

摘要：

This paper investigates optimization problem of the cutting parameters in high-speed milling on NAK80 mold steel. An experiment based on the technology of Taguchi is performed. The objective is to establish a correlation among spindle speed, feed per tooth and depth of cut to the three directions of cutting force in the milling process. In this study, the optimum cutting parameters are obtained by the grey relational analysis. Moreover, the principal component analysis is applied to evaluate the weights so that their relative significance can be described properly and objectively. The results of experiments show that grey relational analysis coupled with principal component analysis can effectively acquire the optimal combination of cutting parameters and the proposed approach can be a useful tool to reduce the cutting force.

关键词： high-speed milling     grey relational analysis     principal component analysis     parameters optimization    

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整合药学发展的战略思考

张勇,赵一秀,杨宝峰

《中国工程科学》 2021年 第23卷 第1期   页码 185-192 doi: 10.15302/J-SSCAE-2021.01.022

摘要：

整合药学是以现代药学为基础、随着人类对复杂性疾病认识的日益深刻而提出来的，涉及新药研发、传统医药创新、 临床药学实践、药学学科建设及人才培养等诸多领域。为推进我国整合药学实践的发展，本文运用文献研究、学术交流、专 家咨询等方法，阐明了整合药学理念及内涵，提出了整合药学的未来发展战略。研究指出，要促进现代药学与传统药学的整 合，应建立健全整合用药临床实践指南、鼓励基于整合思维的创新中药研究、规范整合中西药临床应用；推进基于整合药学 的新药研发，应创新整合药物设计思路、开发适应整合药学的药物评价体系、加快建设整合药物的新药研发体系；推进整合 药学的临床实践，应进一步完善以患者为中心的临床用药指导、实现个体化治疗、丰富整合药学临床实践内容、加强整合药 物合理应用；推进整合药学学科建设，应丰富基于整合药学的药学本科理论和实践课程、加强教育培训及专业间协作。整合 药学是现代药学理论和实践的变革与发展，融合药学各相关学科的理论与实践，是构建促进人类健康、完善医疗体系的新型 药学理论和实践体系。

关键词： 整合药学，整合药物，新药研发，药物评价，临床用药指导    

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A systematic approach in load disaggregation utilizing a multi-stage classification algorithm for consumer

Chuan Choong YANG, Chit Siang SOH, Vooi Voon YAP

《能源前沿（英文）》 2019年 第13卷 第2期   页码 386-398 doi: 10.1007/s11708-017-0497-z

摘要： The potential to save energy in existing consumer electrical appliances is very high. One of the ways to achieve energy saving and improve energy use awareness is to recognize the energy consumption of individual electrical appliances. To recognize the energy consumption of consumer electrical appliances, the load disaggregation methodology is utilized. Non-intrusive appliance load monitoring (NIALM) is a load disaggregation methodology that disaggregates the sum of power consumption in a single point into the power consumption of individual electrical appliances. In this study, load disaggregation is performed through voltage and current waveform, known as the - trajectory. The classification algorithm performs cropping and image pyramid reduction of the - trajectory plot template images before utilizing the principal component analysis (PCA) and the -nearest neighbor ( -NN) algorithm. The novelty of this paper is to establish a systematic approach of load disaggregation through - trajectory-based load signature images by utilizing a multi-stage classification algorithm methodology. The contribution of this paper is in utilizing the “ -value,” the number of closest data points to the nearest neighbor, in the -NN algorithm to be effective in classification of electrical appliances. The results of the multi-stage classification algorithm implementation have been discussed and the idea on future work has also been proposed.

关键词： load disaggregation     voltage-current (V-I) trajectory     multi-stage classification algorithm     principal component analysis (PCA)     k-nearest neighbor (k-NN)    

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Taking advantage of drug resistance, a new approach in the war on cancer

null

《医学前沿（英文）》 2018年 第12卷 第4期   页码 490-495 doi: 10.1007/s11684-018-0647-7

摘要：

Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.

关键词： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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An exploratory study for predicting component reliability with new load conditions

Zhengwei HU, Xiaoping DU

《机械工程前沿（英文）》 2019年 第14卷 第1期   页码 76-84 doi: 10.1007/s11465-018-0522-x

摘要： Reliability is important to design innovation. A new product should be not only innovative, but also reliable. For many existing components used in the new product, their reliability will change because the applied Loads are different from the ones for which the components are originally designed and manufactured. Then the new reliability must be re-evaluated. The system designers of the new product, however, may not have enough information to perform this task. With a beam problem as a case study, this study explores a feasible way to re-evaluate the component reliability with new Loads given the following information: The original reliability of the component with respect to the component Loads and the distributions of the new component Loads. Physics-based methods are employed to build the equivalent component limit-state function that can predict the component failure under the new Loads. Since the information is limited, the re-evaluated component reliability is given by its maximum and minimum values. The case study shows that good accuracy can be obtained even though the new reliability is provided with the aforementioned interval.

关键词： reliability     component     failure mode     prediction     random variable    

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基于主成分分析法的秦巴山脉区域林业产业发展研究

郑东晖,后华,翟明普,渠美

《中国工程科学》 2020年 第22卷 第1期   页码 120-126 doi: 10.15302/J-SSCAE-2020.01.013

摘要：

林业产业作为国民经济的重要基础性产业，在生态建设中的地位日益突出。本文系统梳理了秦巴山脉区域的林业产业发展现状，详细开展了区域林业产业的优势、劣势、机遇和威胁（SWOT）分析，以专家问卷调查作为数据来源，运用主成分分析方法，以统计分析的方式寻找出对秦巴山脉林业产业发展有较大影响的要素，以之作为区域林业产业发展战略制定的科学依据。研究表明，生态环境问题、集约化程度低、森林旅游业发展机遇、区位优势、资源优势等方面是秦巴山脉区域林业产业发展的主要影响因素；区域林业产业发展重在于生态建设，应利用区位和资源优势，做大做强特色产业，优化产业结构；同时大力发展以森林旅游为主的第三产业，保障区域林业产业的高质量发展。

关键词： 秦巴山脉区域     林业产业     SWOT分析     主成分分析法     生态环境    

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

《化学科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 116-122 doi: 10.1007/s11705-013-1310-0

摘要： Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy- -PMA). Various grades of Psy- -PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

关键词： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Protein microspheres for pulmonary drug delivery

Yongda SUN,

《化学科学与工程前沿（英文）》 2010年 第4卷 第1期   页码 82-86 doi: 10.1007/s11705-009-0307-1

摘要： A new supercritical fluid (SCF) technique was developed for the preparation of microspheres for pulmonary drug delivery (PDD). This technique, based on the anti-solvent process, has incorporated advanced engineering design features to enable improved control of the particle formation process. Human recombinant insulin (HRI) was used as a model compound to evaluate the efficiency of this SCF process. An aqueous solution of HRI with a co-solvent was sprayed into high pressure carbon dioxide that extracted the solvent and water, leading to a dry fine powder with good particle size distribution and near ideal morphology for pulmonary drug delivery.

关键词： advanced engineering     improved     pressure     aqueous     technique    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

《化学科学与工程前沿（英文）》 2014年 第8卷 第2期   页码 225-232 doi: 10.1007/s11705-014-1429-7

摘要： Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

关键词： controlled release     drug delivery     semi-solids     polymer     excipient    

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Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

《化学科学与工程前沿（英文）》 2012年 第6卷 第3期   页码 246-252 doi: 10.1007/s11705-012-1299-9

摘要： A solvothermal method has been successfully used to prepare nanostructured hydroxyapatite (HA) hollow spheres with average diameters of about 500 nm and shell thicknesses of about 100 nm in a glycerin/water mixed solvent. Transmission electron microscopy (TEM) and field-emission scanning electron microscopy (FESEM) images show that the shells of the HA hollow spheres are actually composed of nanosheets with thicknesses of about 10 nm. By tuning the glycerin/water volume ratio, two other kinds of HA solid spheres with average diameters of about 6 or 20 μm were assembled from nanoflakes. The properties of the different kinds of spheres as drug delivery carriers were evaluated. Ibuprofen (IBU) was chosen as the model drug to load into the HA samples. The nanostructured HA samples showed a slow and sustained release of IBU. The HA hollow spheres exhibited a higher drug loading capacity and more favorable release properties than the HA solid spheres and thus are very promising for controlled drug release applications.

关键词： hydroxyapatite     hollow spheres     synthesis     drug release    

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标题 作者 时间 类型 操作

Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

期刊论文

Molecular level simulations on multi-component systems —a morphology prediction method

C. SCHMIDT, J. ULRICH

期刊论文

Multi-Component Resource Recycling from Waste Light-Emitting Diode Under Hydrothermal Condition: Plastic

Yongliang Zhang,Lu Zhan,Zhenming Xu,

期刊论文

The molecular epidemiological study of colistin-only-sensitive strains in multi-drug resistant Acinetobacter

YANG Li, HAN Lizhong, SUN Jingyong, NI Yuxing, YU Yunsong

期刊论文

Cholera: an overview with reference to the Yemen epidemic

Ali A. Rabaan

期刊论文

Multi-objective optimization of cutting parameters in high-speed milling based on grey relational analysiscoupled with principal component analysis

Tao FU, Jibin ZHAO, Weijun LIU

期刊论文

整合药学发展的战略思考

张勇,赵一秀,杨宝峰

期刊论文

A systematic approach in load disaggregation utilizing a multi-stage classification algorithm for consumer

Chuan Choong YANG, Chit Siang SOH, Vooi Voon YAP

期刊论文

Taking advantage of drug resistance, a new approach in the war on cancer

null

期刊论文

An exploratory study for predicting component reliability with new load conditions

Zhengwei HU, Xiaoping DU

期刊论文

基于主成分分析法的秦巴山脉区域林业产业发展研究

郑东晖,后华,翟明普,渠美

期刊论文

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

期刊论文

Protein microspheres for pulmonary drug delivery

Yongda SUN,

期刊论文

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

期刊论文

Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG, Weixin ZHANG, Zeheng YANG, Zhao ZHANG

期刊论文